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Impacto da interação fármaco-alimento na eficácia do trata mento de doenças da comunidade
(2025-06-26) Yasmin Moraes Gomes de Almeida; Laidy Vittória Acien Pereira; Maycon Bruno de Almeida
Drug interactions occur when the effects of a drug are altered by another drug or food, and
may be physicochemical, pharmacokinetic or pharmacodynamic. Drug-food interactions
involve cytochrome P450 enzymes and P-glycoprotein, impacting the efficacy and safety
of the treatment of diseases in the community. Foods such as grapefruit, dairy products
and alcohol can modify the effects of antihypertensives, antidepressants, NSAIDs and
anticoagulants, among others. Drug-drug interactions (DDIs) account for 26% of adverse
events, increasing hospitalizations. Of the 1658 articles found in PubMed, 40 were selected,
highlighting that food can interfere with the efficacy and safety of antihypertensives,
antidepressants, NSAIDs and anticoagulants, increasing the risk of toxicity and decreasing
absorption, demonstrating the importance of considering diet when prescribing
medications to optimize treatment efficacy and minimize risks. Training healthcare
professionals is crucial to ensuring safe and effective treatment in the community
Choque séptico de origem pulmonar por Acinetobacter baumannii multirresistente em paciente imunocompro metido: relato de caso
(2025-06-26) Sara Oliveira Maia1, Vitor Hugo Silva De Aguiar Ribeiro; Júlia Brasil Barbosa; Letícia Quinteiro Hernandez; Luiz Antônio Eckhardt De Pontes
Infections caused by Acinetobacter baumannii represent a growing challenge for healthcare
services, especially in hospital settings, due to their resistance to antibiotics. This report
addresses the therapeutic management of a severe infection caused by multidrug
resistant A. baumannii in a patient admitted to an intensive care unit (ICU) A 42-year
old man was admitted to the ICU with respiratory distress and fever. Examinations
revealed a severe pulmonary infection, associated with other complications. The
patient was empirically treated with polymyxin B and fluconazole, and subsequently
with meropenem and linezolid. Following initial antimicrobial therapy, cultures were
performed confirming the presence of multidrug-resistant A. baumannii. The antibiogram
revealed resistance to several antibiotics, except for tigecycline. The conduct was
adjusted based on culture results. Managing infections caused by multidrug-resistant A.
baumannii is challenging due to the limited efficacy of available antibiotics. Tigecyclin
has shown effectiveness against multidrug-resistant strains, however, closely monitoring
treatment response and considering therapeutic changes when necessary is essential.
Esclerose tuberosa diagnosticada em idade adulta: um relato de caso
(2025-06-26) Phatryck Lhoran Pinheiro Ferreira; Iara Salvador Pecemilis1, Eduarda Queiroz Amorim; Ramon Gonçalves Romano Cruz Ribeiro
Tuberous sclerosis complex (TSC) or simply tuberous sclerosis (TS), also known as
Bourneville-Pringle disease, is a rare autosomal dominant genetic disease that alters the
mechanisms of cell proliferation, generating hamartomas in several organs. Among the
systems affected, the central nervous system (CNS), skin and skin appendages, kidney,
respiratory, cardiac and ophthalmological systems stand out. The definitive diagnosis
of tuberous sclerosis requires the identif ication of a pathogenic mutation in one of the
genes associated with the disease, TSC1 or TSC2, through molecular genetic testing;
2 major clinical criteria or 1 major clinical criterion and 2 minor clinical criteria. The
treatment of tuberous sclerosis is closely related to the systems affected, considering
that the disease can affect multiple organs simultaneously. Therefore, monitoring by a
multidisciplinary team is essential in order to ensure a comprehensive and individualized
therapeutic approach. Regarding therapeutic strategies, it is also worth highlighting that
the use of targeted therapy with mTORC1 inhibitors is currently an excellent alternative
INDICADORES BIBLIOMÉTRICOS SOBRE O TEMA “DENGUE” E “DENGUE INFANTIL” NA BASE SCOPUS
(2021-10-20) Eliane Cristina Casimiro Alves Dias
Dengue is the most important arbovirus in the world and one of the main
health challenges in Brazil. The scenario of hyperendemicity, with epidemics of great
magnitude and an increase in severe forms of the disease has also led to an
increase in cases in special groups, such as children in whom the clinical
presentation of the disease is nonspecific and can present the severe form of dengue
as the first manifestation without the foreshadowings of warning signs, as in adults.
OBJECTIVE: The objective of this work is to provide an overview of the main
bibliometric indicators on the themes “dengue” and “children's dengue”. METHODS:
A bibliometric search was carried out in the Scopus database, in July 2020, using the
themes “dengue” and “children's dengue” to identify the main authors, institutions,
journals, languages used and areas that most publish on the topic. RESULTS: The
worldwide growth rate in the number of publications on the topic "dengue" and
"infantile dengue" show, on average, respectively 12.9% and 11.6% of growth per
year, therefore higher than the average growth of articles in the Scopus database,
which was 5.3% per year. The United States was the country with the highest
number of publications on the “dengue” theme, followed by India and Brazil. In terms
of “dengue for children”, the United States remained in the ranking of publications,
followed by India, Thailand and then Brazil, where Fiocruz is the main publication
institution for “dengue” and children's dengue”, followed by USP, UFRJ and UFMG.
In the world, Brazilian and US institutions are among the main institutions with the
most publications on the topic of “dengue” and “children's dengue”, followed by
European institutions. The areas that most studied the subject are “medicine”,
“immunology and microbiology” and “biochemistry and genetics”. It was also possible
to know the main Brazilian and world authors, as well as the periodicals in which
Brazilians and other authors publish the most on the subject. CONCLUSIONS: It can
be concluded that the theme “dengue” and “infantile dengue” have great relevance in
scientific research, having seen the impact on public health in Brazil and in the world
and represent a significant portion of morbidity and mortality in the pediatric age
group nowadays.
Falando com bebês: da detecção de sinais de risco para Autismo à intervenção precoce
(2018-03-09) Odila Maria Ferreira de Carvalho Mansur
The autism spectrum disorder (ASD) cases are characterized by qualitative
impairments in social and communication behavior and a restricted range of activities
moreover, restrict interests. On the other hand, there are needs for intervention together with
the scarcity of licensed professionals to do the intervention in children with ASD. The
objective of this work was to examine the effects of a parent/caregivers training program in
their children‟s outcome. Participated in this study three children diagnosed or suspected ASD
with 08, 16 and 18 moths-old and their caregivers. That research was quasi-experimental,
within-subjects, AB-based therapy – baseline, treatment, and follow-up. Moreover, effect size
measures for single-case designs was check with a non-overlapping index, TAU-U. The
interventions were made at Interdisciplinary ambulatory of Plantadores de Cana Hospital,
Campos dos Goytacazes city, in Rio de Janeiro state. The caregivers and their children were
evaluated by 40 minutes sessions once a week for a year; their performance was reviewed in
each session. There was an individualized developmental model program for each child. The
playful atmosphere was a priority, aiming to set up a social interaction between children and
their caregivers, as well as higher participation rates. The subject of study, Izabel has the best
answer to intervention; only she has an improvement in the interaction initiatives. She also
has advanced in body language, and facial expressions answer rates. Ana, the second child,
has improved in body language and language skills. The third child, Márcia had a statistically
significant increase of mixed (face and body language) answer rates. No statistically
significant changes were found in others variables. However, the treatment makes a positive
and noticeable clinical improvement in children. For example, Izabel show elevated face and
total expressions answer rates, and Márcia improved her body language initiative. Regarding
the caregivers, the Márcia‟ caregivers was highlighted with the increase use frequencies of
two strategies: call the child for her name and play with the child by touch, stimulating a
smile answer. The Ana‟ and Izabel‟ caregivers increase use frequencies only on strategy: use
children‟s songs and make a funny or complimentary comment for the child to play again.
The effect of the early intervention program in the performance of the research subjects was
evaluated. We conclude that the intervention program for the caregivers influenced, in a
statistically significant way, in the frequency of shifts and modality of responses in children.
From the data, it can be concluded that the caregiver intervention, guided by a professional,
can be effective and appropriate to the Brazilian socioeconomic context, which government
programs and qualified professionals lack to conduct interventions in the early autism
treatment.